Antibiotic resistance is increasing at an alarming rate, especially in the case of M. tuberculosis. Alternatives to traditional antibiotics are urgently needed to combat these resistant bacteria. Disrupting bacterial, but not mammalian, outer-membrane integrity with peptides is one such strategy to destroy toxic bacteria in a highly selective manner. Design strategies to develop potent, stable antimicrobial peptides stemming from a fundamental understanding of their mechanism of cell disruption are urgently needed.

Time of flight PET (TOF-PET) is an advance over traditional PET that uses the time difference in detection of the two photon events. TOF information provides better localization of the annihilation event along the line formed by each detector pair, resulting in an overall improvement in signal to noise ratio (SNR) of the reconstructed image. This technology uses a direct estimation of the sinogram only from TOF PET data.

Computed Tomography (CT) is an important tool in diagnostic imaging. It plays a key role in diagnosis and intervention. Many advanced CT systems use wide detector arrays, multiple sources, andor very fast rotation speed, for important clinical applications (e.g., coronary artery and whole organ perfusion imaging). As a result, modern CT scanners are expensive and are typically used by major hospitals and clinics in developed countries. Over the past decades, CT systems or methods have been proposed assuming linear translation-based scanning.

Hollow gold nanoparticles, also known as gold nanocages, are effective vehicles for the transport and administration of therapeutic agents, bioactive compounds, biomolecular reagents, biocatalysts, and other molecular compounds of interest. However, better control of the bioavailability of gold nanocages content is needed. The patent describes a gold nanocage with pores, charged ligand molecules covalently bound to internal surfaces of the gold nanocage, and payload molecules electrostatically adsorbed onto the charged ligand molecules.

Rensselaer researchers have developed a simple algorithm designed to safely modulate insulin delivery and prevent hypoglycemia in outpatients using a continuous glucose monitor (CGM) and insulin pump. This technology applies a Kalman filter to the readings from a CGM to estimate the value and rate of change of the glucose level. This estimate is then used to predict current or impending low blood glucose levels. Then it suspends baseline insulin delivery if the algorithm identifies a risk of hyperglycemia.

Many times following orthopedic surgery or injury to lower extremeties patients are advised to gradually bear weight on their limb. Since patients do not want to cause further damage or pain to the injury they put little to no weight on the area. The application is necessary, however, for proper recovery. This invention is a mechanical device that indicates to the patient when a first level of weight is applied. So, this encourages them to step firmly enough to reach this level without fear that they are going to hurt themselves or cause pain.

The unique properties of carbon nanotubes (CNT), more specifically, single walled carbone nanotubes (SWNT), have made them excellent candidates for applications in bio-sensing, fuel cells, and nanofabrication. Considerable research effort has been devoted to development of methods to achieve stable suspensions of highly dispersed CNTs. However, progress has been impeded by two major hurdles. FIrst, their poor solubility in both aqueous and organic solvents makes them difficult to manipulate and functionalize.

Ambulatory assist devices, such as walkers, typically reduce stress and strain on the musculoskeletal system, allowing the user to move about with greater ease. However, current ambulatory assisting devices fail to provide assistance for a relatively common bodily motion: transitioning from a sitting position to a standing position. This invention is directed to a walker device that provides support and assistance to seniors and rehabilitation patients.

Many proteins lose enzymatic activity in harsh environments, such as non-optimal pH or temperature, or exposure to organic solvents. This invention is based on the discovery that by attaching certain proteins to single-walled carbon nanotubes ("SWNT"), protein function under such harsh conditions can be dramatically improved. Two enzymes which were stabilized in this manner, subtilisin carlsberg and soybean peroxidase, were found to be orders of magnitude more active than the native state enzyme when exposed to severe environments. Additionally, the enzymes attached to the SWNTs w

Electrical impedance tomography (EIT) utilizes electrodes placed on the surface of a body to determine the complex conductivity distribution within the body. When using a voltage source in EIT, it is necessary to know both the applied voltage and the resulting current with high precision, which cannot be achieved with current systems.