Use of E.coli co-cultures for the production of flavonoids

Metabolic engineering and synthetic biology have enabled the use of microbial production platforms for the renewable production of many high-value natural products. Titers and yields, however, are often too low to result in commercially viable processes. Microbial co-cultures have the ability to distribute metabolic burden and allow for modular specific optimization in a way that is not possible through traditional monoculture fermentation methods. Rensselaer Inventors created a new type of E.

UVB, Artificial Sunlight Device for Vitamin-D Production

Unlike vitamin D supplements, phototherapy provides a more natural means of vitamin D production. While research has shown that the vitamin D received from supplements is functionally equivalent to that synthesized from natural sunlight, evidence suggests that vitamin D sourced from sunlight remains active in our bodies longer than vitamin D derived from dietary supplements. Studies have further demonstrated that compared to natural sunlight, UVB LEDs are more efficient and more effective in producing vitamin D3 in skin.

3D FEW-VIEW CT IMAGE RECONSTRUCTION FROM PROJECTION DATA

Inventors at RPI have invented a technology that can overcome the issues seen in few-view CT scans. CT scans use a large number of X-rays exposing the patient to ionizing radiation during this procedure. Though the risk of cancer from a CT scan might be extremely low, there is still a concern that the combined risks of scanning for diagnoses and/or treatment could lead to a greater number of cancers in the future. Few-view CT image reconstruction is an important approach to reduce the ionizing radiation dose.

UNAFold version 4.0

Based on the famous ""mfold"", the UNAFold software package is an integrated collection of programs that simulate nucleic acid folding and hybridization, and its melting pathways for one or two single-stranded molecules. The package predicts folding for single-stranded RNA or DNA through combination of free energy minimization, partition function calculations and stochastic sampling. For melting simulations, the package computes entire melting profiles, not just melting temperatures.

Use of HCV NS3/4A Protease Inhibitors as Therapeutics for COVID-19

The SARS-CoV-2 virus continues to cause major issues around the globe. Thus, effective therapeutics are critically needed to help better control the virus. Researchers at RPI and collaborating institutions have identified HCV protease inhibitor drugs that may be viable SARS-CoV-2 antivirals. These researchers have used the 3D structure of the SARS-CoV-2 protease to evaluate the potential for 12 FDA-approved HCV drugs to inhibit the SARS-CoV-2 protease.

RECON

RECON is an algorithm for the rapid reconstruction of molecular charge densities and charge density-based electronic properties of molecules, using atomic charge density fragments precomputed from ab initio wave functions. The method is based on Bader's quantum theory of Atoms in Molecules. A library of atomic charge density fragments has been built in a form that allows for the rapid retrieval of the fragments and molecular assembly.

MULTIPLEX DETECTION OF BACTERIAL PATHOGENS VIA CELL WALL BINDING DOMAIN COMPLEXES

The rapid detection of pathogens and other microbial contaminants in food and biological samples is critical for ensuring the safety of consumers. Traditional methods to detect foodborne bacteria often rely on time-consuming growth in culture media, followed by isolation, biochemical identification, and sometimes serology. The enzyme-linked immunosorbent assay (ELISA) is the most prevalent antibody assay format used for pathogen detection in foods.

Three-dimensional scaffolds, methods for fabricating the same, and methods of treating a peripheral nerve or spinal cord injury

Spinal Cord Injury (SCI) can result in catastrophic loss of function. In the US, 450,000 people live with SCI. Ongoing neuroscience research focuses on ways to improve nervous tissue regeneration, including development of innovative biomaterials. Implantable scaffolds composed of aligned polymer fibers have shown considerable promise in directing regenerating axons in vitro and in vivo. Highly aligned polymer fibers are necessary for neural tissue engineering applications to ensure that axonal extension occurs efficiently through a regenerating environment.

3D determination of cell chirality

Detecting differences at the cellular level is an ongoing problem which, if successfully addressed, could help solve several prevalent ailments, including cancers and prenatal diseases. Normal tissue function requires appropriate cell positioning and directional motion. This property, known as chirality, can be altered by genetic and environmental factors, leading to, for example, birth defects and tumor formation. Current methods to diagnose cancer are based on biomarkers, imaging, and analysis of tissue specimens.

Synthetic membranes and methods of use thereof

Standard interfacial polymerization and phase inversion based-membranes are complex, sensitive to small changes, susceptible to residual chlorine, and have rough surfaces enabling unfavorable adsorption. There is an urgent need to improve synthetic membrane filtration performance for systems which recover biofuels in energy production and desalinize sea and brackish water for potable use. This technology includes a new class of tunable, selective, synthetic membranes and process of making thereof, which outperform commercially available membranes.