INTERNALIZATION OF PROTEINS INTO HOLLOWED GOLD NANOSTRUCTURES

Hollow gold nanoparticles, also known as gold nanocages, are effective vehicles for the transport and administration of therapeutic agents, bioactive compounds, biomolecular reagents, biocatalysts, and other molecular compounds of interest. However, better control of the bioavailability of gold nanocages content is needed. The patent describes a gold nanocage with pores, charged ligand molecules covalently bound to internal surfaces of the gold nanocage, and payload molecules electrostatically adsorbed onto the charged ligand molecules.