Anti-microbial peptides and method for designing novel anti-microbial peptides
Antibiotic resistance is increasing at an alarming rate, especially in the case of M. tuberculosis. Alternatives to traditional antibiotics are urgently needed to combat these resistant bacteria. Disrupting bacterial, but not mammalian, outer-membrane integrity with peptides is one such strategy to destroy toxic bacteria in a highly selective manner. Design strategies to develop potent, stable antimicrobial peptides stemming from a fundamental understanding of their mechanism of cell disruption are urgently needed.