Intramembrane proteolytic cleavage is an important process in a number of signaling pathways and pathologies. One of the best-known is that of Alzheimer’s Disease (AD), where the gamma-secretase enzyme cleaves amyloid precursor protein (APP) to create free amyloid. This free amyloid accumulates to form amyloid plaques during the later stages of the disease. New drugs are urgently needed to address AD and the disclosed compound represents such potential drug. This technology is a compound that can bind and covalently modify the transmembrane (TM) domain of the amyloid precursor protein.
Nonphotochemical quenching (NPQ) is a response mechanism in plants and algae that allows them to process and dissipate excess excitation energy as heat safely. Collecting fluorescence data from these plants and algae in surface water environments can incur errors from NPQ, ultimately leading to inaccurate calculations of chlorophyll concentration for environmental and industrial water quality monitoring. Rensselaer inventors developed a novel approach to correcting NPQ-skewed fluorescence data by employing trained machine-learning modules that can be applied to fluorescence detection system
The crystalline lenses of the eyes undergo mechanical, physiological, morphological and refractive changes to adjust the total refractive power of the eyes to maintain sharp visual acuity whenever an object of regard is moved toward and away from the distance at which humans typically view reading material. The aggregate changes experienced by the crystalline lenses of the eyes to maintain sharp visual acuity is referred to as accommodation. At any given time the crystalline lenses and the eyes may be regarded as being in a state of accommodation.