Recently, Terahertz time domain spectroscopy (THz-TDS) has emerged as a successful method to measure the refractive index of thin solid films without sample perturbation. However, a need remains for a new non-invasive biosensor technology having application, for example, in healthcare, food monitoring, and weapon detection. This invention is directed to a method for detecting specific associations between a tethered molecule and an untethered target molecule, thus providing a method of probing bimolecular interactions using THz radiation.

After discovering that a natural product has a particular, useful biological activity, it is desirable to prepare analogs of the natural product. However, natural products and their analogs are typically complex molecules requiring multi-step syntheses that are usually laborious, costly, and time consuming. This invention is directed to a microfluidics device that can be used to prepare natural products and their analogs.

This invention is directed to a step-wise enzymatic synthesis of combinatorial libraries of polymeric compounds prepared on a solid support in a configuration suitable for high-throughput screening for use in drug discovery and related fields. This invention provides compositions and methods for generating and screening libraries of phenolicanilinic polymers (and their related quinine forms) attached to a suitable surface and synthesized using enzymatic catalysis.

Displacement chromatography is a powerful preparative technique that can offer high production rates, resolving power and elevated yields and purity of a desired byproduct. Historically, it was necessary to screen displacer candidates individually in column experiments using trial and error, a very laborious task.