Displacement chromatography has attracted signifcant attention as a powerful technique for the purification of bioherapeutic proteins and oligunucleotides. Displacement chromatography enables simultaneous concentration and purification in a single step, which is significant in the purifcation of biopharmaceuticals. However, the major obstacle in implementing this technique is the lack of a sufficient diversity of appropriate displace candidates that are applicable across a wide spectrum of bioseparation demands.
Displacement chromatography is a powerful preparative technique that can offer high production rates, resolving power and elevated yields and purity of a desired byproduct. Historically, it was necessary to screen displacer candidates individually in column experiments using trial and error, a very laborious task.