Aminoglycoside-Polyamine Displacers for Displacement Chromatography

Displacement chromatography has attracted signifcant attention as a powerful technique for the purification of bioherapeutic proteins and oligunucleotides. Displacement chromatography enables simultaneous concentration and purification in a single step, which is significant in the purifcation of biopharmaceuticals. However, the major obstacle in implementing this technique is the lack of a sufficient diversity of appropriate displace candidates that are applicable across a wide spectrum of bioseparation demands.