This invention is directed to a step-wise enzymatic synthesis of combinatorial libraries of polymeric compounds prepared on a solid support in a configuration suitable for high-throughput screening for use in drug discovery and related fields. This invention provides compositions and methods for generating and screening libraries of phenolicanilinic polymers (and their related quinine forms) attached to a suitable surface and synthesized using enzymatic catalysis.

Displacement chromatography is a powerful preparative technique that can offer high production rates, resolving power and elevated yields and purity of a desired byproduct. Historically, it was necessary to screen displacer candidates individually in column experiments using trial and error, a very laborious task.